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TP0586532 CAS No.: 2427584-96-9

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    Jiangsu

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    Long-term effective

  • Last update:

    2023-10-18 10:02

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    285

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Product Details

Chemical Structure : TP0586532

CAS No.: 2427584-96-9

 

TP0586532 (TP 0586532)

Catalog No.: URK-V603  Only Used For Lab.

TP0586532 (TP 0586532) is a novel non-hydroxamate inhibitor of UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with IC50 of 0.101 uM, shows MIC values 2 mg/mL and 4 mg/mL for E. coli ATCC 25922 and K. pneumoniae ATCC 13883.

 

Biological Activity

TP0586532 (TP 0586532) is a novel non-hydroxamate inhibitor of UDP-3-O-acyl-N--acetylglucosamine deacetylase (LpxC) with IC50 of 0.101 uM, shows MIC values 2 mg/mL and 4 mg/mL for E. coli ATCC 25922 and K. pneumoniae ATCC 13883; TP0586532 is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk. The MIC90 of TP0586532 against clinical isolates of carbapenem-resistant Klebsiella pneumoniae was 4 ug/mL. TP0586532 also showed an in vivo efficacy against murine systemic, urinary tract and lung infection models caused by meropenem- or ciprofloxacin-resistant strains. TP0586532 also reduces LPS release and IL-6 production both in vitro and in vivo.

 

Physicochemical Properties

M.Wt

560.534

Formula

C26H28N4O4

CAS No.

2427584-96-9

Storage

Solide Powder

-20 °C 3years;

4°C 2years

In Solvent

-80°C 6 Months

-20°C 1 Months

Solubility

 

Chemical Name

 

 

References

1. Ushiyama F, et al. Bioorg Med Chem. 2021 Jan 15;30:115964.

2. Fujita K, et al. J Antibiot (Tokyo). 2022 Feb;75(2):98-107.

3. Fujita K, et al. J Antibiot (Tokyo). 2022 Mar;75(3):136-145.

URK-V603_COA
URK-V603_SDS
URK-V603_TDS

 

Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use!

 

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